A summary of ontologies, infrastructures and functions included in dcGOR.

<p>A summary of ontologies, infrastructures and functions included in dcGOR.</p

Enrichment analysis of promiscuous Pfam domains using GOBP terms (left) and GOMF terms (right).

<p>Only the most significant terms/nodes (adjusted p-values<0.05; outlined in black) are visualised along with their ancestral terms. Nodes are coloured according to adjusted p-values.</p

Heatmap visualisation of the GO overall semantic similarity between pairs of promiscuous Pfam domains.

<p>Domains are ordered according to hierarchical clustering by the package ‘supraHex’.</p

In-depth analysis for network-level understanding.

<p>(<b>A</b>) Heatmap visualisation of the semantic similarity between pairs of domains according to their annotations by Disease Ontology (DO). (<b>B</b>) Network representation of the pairwise domain semantic similarity. It is a weighted and undirected network, with edge thickness indicating semantic similarity between a pair of domains/nodes. Nodes are labeled by both numeric id and textual description. (<b>C</b>) A table listing GOMF terms and their annotated domains (used as domain seeds for random walk with restart, RWR). Notably, terms used here are only those with at least 3 annotatable domains that are also in the domain network (see <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1003929#pcbi-1003929-g002" target="_blank">Figure 2B</a>). (<b>D</b>) Contact (statistical significance) network between GOMF terms in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1003929#pcbi-1003929-g002" target="_blank">Figure 2C</a>, as estimated by RWR on the domain network in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1003929#pcbi-1003929-g002" target="_blank">Figure 2B</a>. Only those significant contacts/edges (adjusted p-values<0.1) are shown, with thickness indicating the contact strength (z-score).</p

Test loading device.

<p>(a) Uniform loading. (b) Concentrated loading.</p

Relationship between the specimen load and web density.

<p>Relationship between the specimen load and web density.</p

Mechanical model of the simulated sandwich panel.

<p>Mechanical model of the simulated sandwich panel.</p

Load-deflection curves of the specimens.

<p>Load-deflection curves of the specimens.</p

Schematic diagram of an original sandwich panel and the corresponding simulated sandwich panel.

<p>Schematic diagram of an original sandwich panel and the corresponding simulated sandwich panel.</p

Fracture failure of the upper face sheet.

<p>(a) SX50-75. (b) SX75-75. (c) SX100-75. (d) SX75-125.</p